fosphenytoin will minimize the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
apalutamide will reduce the extent or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medicines which might be CYP2C19 substrates may result in reduced exposure to these remedies.
Check Intently (one)ethinylestradiol will improve the level or outcome of diazepam by System: reducing metabolism.
Monitor Closely (1)diazepam will enhance the degree or outcome of finerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
lapatinib will raise the stage or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
benzhydrocodone/acetaminophen and diazepam the two raise sedation. Prevent or Use Alternate Drug. Restrict use to people for whom alternative cure selections are inadequate
Valium is indicated for your administration of panic Conditions or for the limited-phrase aid of your signs or symptoms of nervousness. Stress and anxiety or tension associated with the tension of daily life commonly won't involve remedy with an anxiolytic.
Normally, diazepam is helpful from the symptomatic administration of delicate to average degrees of anxiety in disorders dominated by pressure, excitation, agitation, fear, or aggressiveness for instance may well come about in psychoneurosis, stress and anxiety reactions as a result of anxiety problems, and nervousness states with somatic expression.sixteen
methylprednisolone will lessen the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Diazepam may well interfere with metabolism of substrates for CYP2C19 and CYP3A4 bringing about a possible drug-drug conversation
Also, diazepam is really a practical adjunct for the relief of skeletal muscle mass spasm because of reflex spasm to neighborhood pathologies, including inflammation in the muscle and joints or secondary to trauma; spasticity attributable to upper motor neuron disorders, which include cerebral palsy and paraplegia; athetosis along with the uncommon "rigid gentleman syndrome".16
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diazepam will increase the amount or influence of flibanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Elevated flibanserin adverse consequences may perhaps occur if coadministered with many weak CYP3A4 inhibitors.
diazepam improves toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Watch Closely. Reports have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling impact on buprenorphine-induced respiratory depression, creating the respiratory consequences of buprenorphine appear comparable to These of total opioid agonists.